Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 150
interventional 121
Observational 27
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug|placebo 43
Drug 37
Other 8
Drug|Other 5
Device 4
Device|Procedure 4
Procedure 4
Behavioral 2
Device|placebo 2
Diagnostic Test 2
Dietary Supplement 2
Dietary Supplement|placebo 2
Behavioral|Drug 1
Biological 1
Device|Drug 1
Device|Drug|placebo 1
Diagnostic Test|Other|Procedure 1
placebo|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 25
United Kingdom 15
Canada 13
NA 10
Korea, Republic of 6
China 4
France 3
Israel 3
Italy 3
Japan 3
Brazil 2
Colombia 2
Germany 2
Netherlands 2
Netherlands|United Kingdom 2
Poland 2
Taiwan 2
United States|United Kingdom 2
Argentina 1
Australia 1
Bulgaria 1
Chile|Peru 1
Finland 1
Iran, Islamic Republic of 1
Ireland|United Kingdom 1
Nepal 1
Pakistan 1
Russian Federation 1
Spain 1
Sweden 1
Switzerland 1
Thailand 1
Tunisia 1
Turkey 1
United States|Argentina|Canada|Czechia|Denmark|France|Hungary|Israel|Japan|Korea, Republic of|Peru|Poland|Spain|Taiwan|Turkey|Ukraine|United Kingdom 1
United States|Argentina|Germany|Guatemala|Israel|Korea, Republic of|Russian Federation|Spain|Ukraine|United Kingdom 1
United States|Australia|Canada|China|Colombia|Czechia|Denmark|Germany|Guatemala|Hungary|Israel|Italy|Malaysia|New Zealand|Peru|Poland|South Africa|Turkey|Ukraine|United Kingdom 1
United States|Germany|Guatemala|Korea, Republic of|Poland|Russian Federation|Spain|Ukraine 1

Sites per Study

Site_count Study_Count
1 90
2 4
4 3
5 4
7 3
8 3
10 1
11 1
12 1
13 1
16 1
17 2
39 1
42 1
46 1
50 1
61 1
156 1
171 1

Phase

Phase Study_Count
N/A 46
Phase 2 31
Phase 4 18
Phase 3 16
Phase 1 5
Phase 1/Phase 2 5

Number of Arms

Number_of_Arms Count_of_Studies
1 15
2 68
3 15
4 12
6 3
7 1
NA 7

Enrollment Metrics by Phase

Measure N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.3 Phase.4
Min. 6.0000 20.0 25 14.00000 25.000 14.0000
1st Qu. 27.0000 31.0 40 25.75000 101.250 32.5000
Median 55.0000 36.0 44 50.50000 222.000 94.5000
Mean 96.8913 45.6 51 90.43333 306.375 124.6667
3rd Qu. 120.0000 36.0 59 89.00000 384.000 147.7500
Max. 820.0000 105.0 87 372.00000 1290.000 500.0000

Trial Group Type

group_type Group_Count
Experimental 149
Placebo Comparator 57
Active Comparator 52
NA 7
Other 6
No Intervention 3
Sham Comparator 2

Intervention Model

intervention_model Study_Count
Parallel Assignment 73
Crossover Assignment 26
Single Group Assignment 17
Factorial Assignment 3
Sequential Assignment 2

Primary Purpose

primary_purpose Study_Count
Treatment 81
Prevention 16
Basic Science 8
Diagnostic 7
Other 5
NA 2
Health Services Research 1
Supportive Care 1

Observational Studies

Studies by Country

Country Study_Count
United States 7
United Kingdom 6
China 3
France 2
Israel 2
Poland 2
Italy 1
Korea, Republic of 1
Slovakia 1
Switzerland 1
Turkey 1

Sites per Study

Site_count Study_Count
1 25
3 1
32 1

Enrollment Metrics

Measure Observational
Min 15.0000
1st Qu 54.5000
Median 80.0000
Mean 357.4444
3rd Qu 100.0000
Max 3402.0000

Observation Model

observational_model Study_Count
Cohort 12
Case-Only 5
Case-Control 4
Case Control 4
NA 2

Time Perspective

time_perspective Study_Count
Prospective 19
Cross-Sectional 7
Retrospective 1

Registries

Studies by Country

Country Study_Count
China 1
Norway 1

Sites per Study

Site_count Study_Count
1 2

Enrollment Metrics

Measure Registries
Min 72
1st Qu 84
Median 96
Mean 96
3rd Qu 108
Max 120

Registry Model

observational_model Study_Count
Cohort 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 2

Follow-up

target_duration Study_Count
1 Day 1
3 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03235466 A Prospective Trial of Behavioral Therapy for Chronic Cough https://ClinicalTrials.gov/show/NCT03235466 Recruiting University of California, San Diego 2020-06-01
NCT04457011 Efficacy and Safety of Susu Zhike Granules for Treating Acute Cough Due to Common Cold With Cold-cough Syndrome in Children https://ClinicalTrials.gov/show/NCT04457011 Recruiting Tasly Pharmaceutical Group Co., Ltd 2022-04-30
NCT04421092 Efficacy of SLN Block for Chronic Cough https://ClinicalTrials.gov/show/NCT04421092 Recruiting Medical University of South Carolina 2020-09-30
NCT04203810 Effectiveness and Tolerability of Ectoin® Mouth and Throat Spray Althaea Honey (ERS09) https://ClinicalTrials.gov/show/NCT04203810 Recruiting Bitop AG 2020-12-31
NCT04110054 Evaluation of S-600918 in Adults With Refractory Chronic Cough https://ClinicalTrials.gov/show/NCT04110054 Recruiting Shionogi Inc. 2021-05-25
NCT01990781 Effect of Intravenous Lidocaine and Dexamethasone Combination on Postoperative Sore Throat, Cough and Hoarseness. https://ClinicalTrials.gov/show/NCT01990781 Completed B.P. Koirala Institute of Health Sciences 2015-12-31
NCT01368809 Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management https://ClinicalTrials.gov/show/NCT01368809 Completed Cedars-Sinai Medical Center 2013-02-28
NCT00858624 Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity https://ClinicalTrials.gov/show/NCT00858624 Completed University of Manchester 2009-07-31
NCT03310645 Repeat Doses of BAY 1817080 in Healthy Males & Proof of Concept in Chronic Cough Patients https://ClinicalTrials.gov/show/NCT03310645 Completed Bayer 2019-05-28
NCT03282591 Study of the Efficacy, Safety, and Tolerability of Serlopitant for the Treatment of Refractory Chronic Cough https://ClinicalTrials.gov/show/NCT03282591 Completed Menlo Therapeutics Inc. 2018-08-15
NCT03172130 Sham CPAP vs. Straight CPAP for Chronic Cough https://ClinicalTrials.gov/show/NCT03172130 Completed University of Utah 2019-11-25
NCT03135522 Pilot of Zinc Acetate to Improve Chronic Cough https://ClinicalTrials.gov/show/NCT03135522 Completed Johns Hopkins University 2019-12-11
NCT03132519 Optimal Remifentanil Ce for Preventing Severe Cough and Hyperdynamic Response During Tracheal Extubation https://ClinicalTrials.gov/show/NCT03132519 Completed Fundacion Clinica Valle del Lili 2015-11-30
NCT03100565 Lidocaine Spray vs Coughing for Pain Relief During Colposcopy https://ClinicalTrials.gov/show/NCT03100565 Completed Yuzuncu Yıl University 2018-03-08
NCT02993822 A Dose-ranging Study of Orvepitant in Patients With Chronic Refractory Cough https://ClinicalTrials.gov/show/NCT02993822 Completed Nerre Therapeutics Ltd. 2019-02-11
NCT02981147 PEACe: Ivy, Thyme and Cisti Extract (Phytus) Efficacy in Acute Cough https://ClinicalTrials.gov/show/NCT02981147 Completed PharmEvo Pvt Ltd 2017-12-30
NCT02957045 Alternative Measurements of Cough Pressure and Effects of Epidural Anaesthesia on Cough Pressure https://ClinicalTrials.gov/show/NCT02957045 Completed Parc de Salut Mar 2008-05-31
NCT02932397 Efficacy of Propofol vs Placebo in the Prevention of Coughing During Emergence of General Anesthesia Under Desflurane https://ClinicalTrials.gov/show/NCT02932397 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2017-12-31
NCT01575821 The Effect of Honey on Nocturnal Cough and Sleep Quality https://ClinicalTrials.gov/show/NCT01575821 Completed Meir Medical Center 2012-04-30
NCT02882555 Effect of Muscular Exercise on Cough Reflex https://ClinicalTrials.gov/show/NCT02882555 Completed Central Hospital, Nancy, France 2013-12-31
NCT02711904 Concentrations of Remifentanil for Extubation https://ClinicalTrials.gov/show/NCT02711904 Completed Seganest 2011-01-31
NCT02651116 Dextromethorphan Pediatric Acute Cough Study https://ClinicalTrials.gov/show/NCT02651116 Active, not recruiting Pfizer 2020-04-30
NCT02502097 A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016) https://ClinicalTrials.gov/show/NCT02502097 Completed Afferent Pharmaceuticals, Inc. 2016-07-01
NCT04193202 Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043) https://ClinicalTrials.gov/show/NCT04193202 Recruiting Merck Sharp & Dohme Corp. 2021-04-07
NCT02566512 Assessment of Cough Strength in Patients With Tracheostomies https://ClinicalTrials.gov/show/NCT02566512 Completed University of Manitoba 2018-09-30
NCT01774305 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy https://ClinicalTrials.gov/show/NCT01774305 Completed Yonsei University 2013-01-31
NCT02479074 The Utility of feNO in the Differential Diagnosis of Chronic Cough https://ClinicalTrials.gov/show/NCT02479074 Completed Hull University Teaching Hospitals NHS Trust 2017-02-10
NCT04356625 Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure https://ClinicalTrials.gov/show/NCT04356625 Completed Hospital Nacional Profesor Alejandro Posadas 2019-09-01
NCT02412020 Treatment of Refractory Chronic Cough With PA101 https://ClinicalTrials.gov/show/NCT02412020 Completed Patara Pharma 2016-01-31
NCT04247997 Effect of Disconnecting Pulmonary Vagus Nerve Branch on Chronic Cough After Unilateral Thoracoscopic Lobectomy https://ClinicalTrials.gov/show/NCT04247997 Recruiting Xuzhou Medical University 2021-05-01
NCT02397460 Effect of Gefapixant (AF-219/MK-7264) on Cough Reflex Sensitivity https://ClinicalTrials.gov/show/NCT02397460 Completed Afferent Pharmaceuticals, Inc. 2016-04-22
NCT02396706 RCT to Evaluate the Efficacy and Safety of Ivy Leaves Cough Liquid vs. Placebo in the Treatment of Acute Cough https://ClinicalTrials.gov/show/NCT02396706 Completed Engelhard Arzneimittel GmbH & Co.KG 2015-06-30
NCT02379637 Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough https://ClinicalTrials.gov/show/NCT02379637 Completed Novartis 2015-04-30
NCT02349425 A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough https://ClinicalTrials.gov/show/NCT02349425 Completed Afferent Pharmaceuticals, Inc. 2016-02-01
NCT02233699 A Study to Assess the Efficacy of XEN-D0501 in Reducing the Cough Frequency in Patients With Chronic Idiopathic Cough https://ClinicalTrials.gov/show/NCT02233699 Completed Xention Ltd 2015-05-31
NCT02203162 Effect of Electronic Cigarette Use on Cough Reflex Sensitivity https://ClinicalTrials.gov/show/NCT02203162 Completed Montefiore Medical Center 2014-12-31
NCT01476098 A Study to Investigate the Effect of SB-705498 on Chronic Cough https://ClinicalTrials.gov/show/NCT01476098 Completed GlaxoSmithKline 2011-12-31
NCT02183519 Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson’s Disease https://ClinicalTrials.gov/show/NCT02183519 Completed University of Florida 2015-08-31
NCT02173145 Azithromycin in Idiopathic Pulmonary Fibrosis https://ClinicalTrials.gov/show/NCT02173145 Completed University Hospital Inselspital, Berne 2019-08-16
NCT02114021 Effect of Betamethasone Gel and Lidocaine Jelly on Sore Throat, Cough and Hoarseness of https://ClinicalTrials.gov/show/NCT02114021 Completed Tehran University of Medical Sciences 2013-03-31
NCT02062710 Antitussive Effect of a Naturally Flavored Syrup Containing Diphenhydramine, Compared With Dextromethorphan and Placebo https://ClinicalTrials.gov/show/NCT02062710 Completed Montefiore Medical Center 2014-06-30
NCT01291849 The Effect-site Concentration of Remifentanil for Preventing Cough During Emergence From Balanced Anesthesia for Nasal Surgery https://ClinicalTrials.gov/show/NCT01291849 Completed Yonsei University NA
NCT02039999 An Investigation Into the Mechanism of Inhalation Cough Challenge https://ClinicalTrials.gov/show/NCT02039999 Completed Hull University Teaching Hospitals NHS Trust 2015-07-31
NCT01968434 Comparison of Efficacy and Tolerability of Two Cough Syrups in Cough Due to Cold in Children. https://ClinicalTrials.gov/show/NCT01968434 Completed Clalit Health Services 2014-03-31
NCT01899768 GSK2339345 Hypertussive Challenge Study https://ClinicalTrials.gov/show/NCT01899768 Completed GlaxoSmithKline 2014-10-31
NCT01888549 Efficacy of Proton Pump Inhibitor for Chronic Cough Caused by Gastroesophageal Reflux; Double-blind, Placebo-controlled, Randomized Clinical Trial https://ClinicalTrials.gov/show/NCT01888549 Completed Yonsei University 2016-02-29
NCT01865422 French Linguistic and Metric Validations of Parent-proxy QOL Chronic Cough Specific Questionnaire (PC-QOL) https://ClinicalTrials.gov/show/NCT01865422 Completed Assistance Publique Hopitaux De Marseille 2014-05-31
NCT01854268 Respiratory Kinematics During Voluntary and Reflex Cough in Healthy Adults https://ClinicalTrials.gov/show/NCT01854268 Completed University of Florida 2014-05-31
NCT01774292 Effect of Intracuff Alkalinized Lidocaine on Coughing Incidence at Extubation https://ClinicalTrials.gov/show/NCT01774292 Completed Université de Sherbrooke 2014-06-30
NCT01721395 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents https://ClinicalTrials.gov/show/NCT01721395 Completed Penn State University 2014-03-31
NCT01715688 Efficacy of Alkalinized Lidocaine in the Endotracheal Tube Cuff on the Incidence of Coughing During Emergence https://ClinicalTrials.gov/show/NCT01715688 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2014-04-30
NCT01703923 An Exploratory Study of FP01 Lozenges in Subjects With Chronic Refractory Cough https://ClinicalTrials.gov/show/NCT01703923 Completed Cerecor Inc 2013-09-30
NCT01659541 Stimulation With Wire Leads to Restore Cough https://ClinicalTrials.gov/show/NCT01659541 Recruiting MetroHealth Medical Center 2020-05-31
NCT01659476 Bronchodilating and Bronchoprotective Effects of Deep Inspirations https://ClinicalTrials.gov/show/NCT01659476 Completed Queen’s University 2017-08-31
NCT01656668 Study of the Safety and Effectiveness of BC1036 Capsules to Treat Frequent Long-Term Cough https://ClinicalTrials.gov/show/NCT01656668 Completed Respicopea Limited 2013-08-31
NCT01597349 Antitussive Effects of FP01 Lozenges in Subjects With Cough Due to Upper Respiratory Tract Infection https://ClinicalTrials.gov/show/NCT01597349 Completed Cerecor Inc 2012-09-30
NCT01587716 A Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK2339345. https://ClinicalTrials.gov/show/NCT01587716 Completed GlaxoSmithKline 2012-07-30
NCT01532466 The Effect of Priming Intravenous Rocuronium on Fentanyl-Induced Coughing https://ClinicalTrials.gov/show/NCT01532466 Completed Taichung Armed Forces General Hospital 2011-10-31
NCT01494636 The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects https://ClinicalTrials.gov/show/NCT01494636 Completed GlaxoSmithKline 2012-03-15
NCT01489072 Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia https://ClinicalTrials.gov/show/NCT01489072 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2012-10-31
NCT01451840 Efficacy of Alkalinized Lidocaine Compared to Remifentanil on the Incidence of Coughing During Emergence of Anesthesia https://ClinicalTrials.gov/show/NCT01451840 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2012-10-31
NCT01432730 A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006) https://ClinicalTrials.gov/show/NCT01432730 Completed Afferent Pharmaceuticals, Inc. 2013-02-07
NCT03126851 Promoting Safe Use of Children’s Cough/Cold Medicines https://ClinicalTrials.gov/show/NCT03126851 Enrolling by invitation NYU Langone Health 2020-12-31
NCT04265781 Study on the Safety of Drug BAY1817080 at Different Doses and the Way the Body Absorbs and Eliminates the Drug in Japanese Healthy Adult Male Participants https://ClinicalTrials.gov/show/NCT04265781 Recruiting Bayer 2020-09-30
NCT03457610 Speech Therapy in the Management of Chronic Cough https://ClinicalTrials.gov/show/NCT03457610 Completed Medical University of Warsaw 2019-12-30
NCT04256733 Cough Desensitization Therapy for Cough Hypersensitivity Syndrome https://ClinicalTrials.gov/show/NCT04256733 Recruiting University of Montana 2020-07-31
NCT04203472 Optimal Type of Inhaler in Cough Variant- or Cough Predominant Asthma https://ClinicalTrials.gov/show/NCT04203472 Recruiting Medical University of Warsaw 2020-10-30
NCT04171180 The Efficacy of Budesonide/Formoterol in Cough Variant Asthma https://ClinicalTrials.gov/show/NCT04171180 Recruiting Second Affiliated Hospital, School of Medicine, Zhejiang University 2020-09-30
NCT04125563 Influence on Cough and Airway Symptoms by Oral Capsaicin https://ClinicalTrials.gov/show/NCT04125563 Recruiting Vastra Gotaland Region 2020-06-01
NCT04090112 Comparison of Effectiveness Between the Combination of Lidocaine Sprayed at Laryngeal Inlet and on the Cuff of Endotracheal Tube Versus Intravenous Lidocaine for Reducing Cough During Extubation https://ClinicalTrials.gov/show/NCT04090112 Completed Khon Kaen University 2019-06-30
NCT04073251 Efficacy, Safety and Palatability of the Syrup “KalobaTuss® Children” for the Treatment of Cough in Children https://ClinicalTrials.gov/show/NCT04073251 Completed Azienda Ospedaliera Universitaria Policlinico “G. Martino” 2019-05-03
NCT04000633 Nebulized Lidocaine to Prevent Cough at Emergence From Anesthesia https://ClinicalTrials.gov/show/NCT04000633 Recruiting Mongi Slim Hospital 2019-12-31
NCT02612623 An 8-Week Refractory Chronic Cough Study (MK-7264-021) https://ClinicalTrials.gov/show/NCT02612623 Completed Afferent Pharmaceuticals, Inc. 2016-05-04
NCT03851393 Validation of Peptestâ„¢ for the Detection of Reflux in Cough https://ClinicalTrials.gov/show/NCT03851393 Completed Hull University Teaching Hospitals NHS Trust 2014-10-31
NCT02482818 Efficacy of Pregabalin on Chronic Cough https://ClinicalTrials.gov/show/NCT02482818 Recruiting Ottawa Hospital Research Institute 2020-05-30
NCT03805282 Intravenous Lidocaine to Supress of Cough Reflex During Anesthesia Emergence https://ClinicalTrials.gov/show/NCT03805282 Recruiting Brasilia University Hospital 2019-12-15
NCT03787511 Chronic Cough and Small Fiber Neuropathy https://ClinicalTrials.gov/show/NCT03787511 Recruiting University Hospital, Toulouse 2021-08-31
NCT03722849 Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients https://ClinicalTrials.gov/show/NCT03722849 Recruiting University of Melbourne 2020-07-30
NCT03696108 A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038) https://ClinicalTrials.gov/show/NCT03696108 Active, not recruiting Merck Sharp & Dohme Corp. 2020-09-30
NCT03662269 Indomethacin for Refractory Chronic Cough https://ClinicalTrials.gov/show/NCT03662269 Recruiting The First Affiliated Hospital of Guangzhou Medical University 2020-08-15
NCT03639727 Cough in Eastern and Central Finland https://ClinicalTrials.gov/show/NCT03639727 Completed Kuopio University Hospital 2018-12-31
NCT03622502 The Effect of Dexmedetomidine for Emergence Cough https://ClinicalTrials.gov/show/NCT03622502 Completed Ajou University School of Medicine 2019-03-22
NCT03622216 A Dose Escalation Study of Bradanicline in Refractory Chronic Cough https://ClinicalTrials.gov/show/NCT03622216 Completed Attenua, Inc. 2019-05-07
NCT03620422 Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma https://ClinicalTrials.gov/show/NCT03620422 Completed McMaster University 2020-01-31
NCT03603522 Probiotics and Capsaicin Evoked Coughs https://ClinicalTrials.gov/show/NCT03603522 Recruiting McMaster University 2020-04-30
NCT03535168 Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients https://ClinicalTrials.gov/show/NCT03535168 Completed Bayer 2019-09-25
NCT03482713 Study of Gefapixant (MK-7264) in Adult Japanese Participants With Unexplained or Refractory Chronic Cough (MK-7264-033) https://ClinicalTrials.gov/show/NCT03482713 Completed Merck Sharp & Dohme Corp. 2018-06-07
NCT03415269 A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough. https://ClinicalTrials.gov/show/NCT03415269 Completed Hull University Teaching Hospitals NHS Trust 2018-04-19
NCT01259674 Evaluation of the Efficacy and Tolerability of ABO/MEG-B-09 in Children With Acute Cough https://ClinicalTrials.gov/show/NCT01259674 Completed Aboca Spa Societa’ Agricola 2011-04-30
NCT01257243 Comparison Between Oxomemazine, Guaifenesin and Potassium Iodate Versus Guaifenesin Monotherapy in Acute Cough Treatment https://ClinicalTrials.gov/show/NCT01257243 Completed EMS 2013-09-30
NCT01252225 Lidocaine: Effect of Lidocaine in Chronic Cough https://ClinicalTrials.gov/show/NCT01252225 Completed Manchester University NHS Foundation Trust 2011-05-31
NCT01064245 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests https://ClinicalTrials.gov/show/NCT01064245 Active, not recruiting Queen’s University 2020-12-31
NCT01026129 Efficacy of Remifentanil Compared to Lidocaine on the Incidence of Coughing During Emergence of Anesthesia https://ClinicalTrials.gov/show/NCT01026129 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2010-06-30
NCT00995215 Sub-study to Spinal Cord Stimulation to Restore Cough https://ClinicalTrials.gov/show/NCT00995215 Completed MetroHealth Medical Center 2017-10-15
NCT00916526 Measurement of Exhaled Nitric Oxide (NO) and Bronchial Provocation Test With Mannitol as a Predictor of Response to Inhaled Corticosteroids in Chronic Cough https://ClinicalTrials.gov/show/NCT00916526 Completed Centre Hospitalier Universitaire de Saint Etienne 2010-09-30
NCT00977366 Neurophysiology of Cough Reflex Hypersensitivity https://ClinicalTrials.gov/show/NCT00977366 Completed University of Manchester 2012-09-30
NCT03837938 Clinical Trial of Efficacy and Safety of Levopront® 30 mg/5 ml in Patients With Dry Cough https://ClinicalTrials.gov/show/NCT03837938 Completed Dompé Farmaceutici S.p.A 2018-03-06
NCT04030026 A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough https://ClinicalTrials.gov/show/NCT04030026 Active, not recruiting Trevi Therapeutics 2021-03-31
NCT02612610 A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012) https://ClinicalTrials.gov/show/NCT02612610 Completed Afferent Pharmaceuticals, Inc. 2016-10-31
NCT04193176 Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042) https://ClinicalTrials.gov/show/NCT04193176 Recruiting Merck Sharp & Dohme Corp. 2021-05-11
NCT03449147 A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) https://ClinicalTrials.gov/show/NCT03449147 Active, not recruiting Merck Sharp & Dohme Corp. 2020-08-21
NCT03449134 Phase 3 Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) https://ClinicalTrials.gov/show/NCT03449134 Active, not recruiting Merck Sharp & Dohme Corp. 2020-06-05
NCT02486835 Efficacy & Tolerability of a Specific Plantain,Thyme and Honey Cough Syrup vs Placebo in Child Cough Due to Common Cold https://ClinicalTrials.gov/show/NCT02486835 Completed Clalit Health Services 2016-04-03
NCT02476890 Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014) https://ClinicalTrials.gov/show/NCT02476890 Completed Afferent Pharmaceuticals, Inc. 2016-10-20
NCT01507792 Iron Repletion in Chronic Cough and Iron Deficiency https://ClinicalTrials.gov/show/NCT01507792 Completed University of Turin, Italy 2011-01-31
NCT03489837 Phase III Study to Evaluate the Efficacy and Safety of HOB-048 CR Tab. in Comparison With HOB-048 Syrup in Patients With Cough Due to Acute or Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03489837 Completed Hyundai Pharm 2018-10-31
NCT01071161 The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough https://ClinicalTrials.gov/show/NCT01071161 Completed Isala 2012-02-29
NCT01754220 Open-label Study of the Effects of Montelukast in Patients With Chronic Cough https://ClinicalTrials.gov/show/NCT01754220 Completed Association Asthma, Bulgaria 2012-12-31
NCT00743990 Effect of Effect of a Medicated Topical Therapy , Petrolatum, and No Treatment on Nocturnal Cough https://ClinicalTrials.gov/show/NCT00743990 Completed Penn State University 2010-03-31
NCT00600028 Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide https://ClinicalTrials.gov/show/NCT00600028 Completed Johns Hopkins University 2011-09-30
NCT00547846 A Phase II Clinical Study of PDC-748 in Patients With Acute Cough https://ClinicalTrials.gov/show/NCT00547846 Completed PhytoHealth Corporation NA
NCT00520754 Efficacy and Safety of Levocetirizine for Treatment of Recurrent Cough Associated With Other Allergic Symptoms in Children https://ClinicalTrials.gov/show/NCT00520754 Completed UCB Pharma 2003-03-31
NCT00506987 Study of the Efficacy and Safety of SCH 486757 in Subjects With Chronic Cough (Study P04887) https://ClinicalTrials.gov/show/NCT00506987 Completed Merck Sharp & Dohme Corp. 2007-11-30
NCT00453765 The Effect of Montelukast in Patients With Chronic Cough and Bronchial Hyperreactivity https://ClinicalTrials.gov/show/NCT00453765 Completed Isala 2010-09-30
NCT00380315 Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher https://ClinicalTrials.gov/show/NCT00380315 Completed Ahn-Gook Pharmaceuticals Co.,Ltd NA
NCT00287339 The Utility of Nexium in Chronic Cough and Reflux Disease https://ClinicalTrials.gov/show/NCT00287339 Completed University of North Carolina, Chapel Hill 2008-09-30
NCT00230230 Comparison of SCH 486757 to Codeine and Placebo in Subjects With Persistent Postviral Cough (Study P03069AM2)(COMPLETED) https://ClinicalTrials.gov/show/NCT00230230 Completed Merck Sharp & Dohme Corp. 2007-04-30
NCT00221351 C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough https://ClinicalTrials.gov/show/NCT00221351 Completed University of California, San Francisco 2006-03-31
NCT00116337 Spinal Cord Stimulation to Restore Cough https://ClinicalTrials.gov/show/NCT00116337 Completed MetroHealth Medical Center 2017-10-10
NCT00506545 Study of the Efficacy and Safety of SCH 619734 in Subjects With Chronic Cough From an Unknown Cause (Study P04888) https://ClinicalTrials.gov/show/NCT00506545 Completed Merck Sharp & Dohme Corp. 2007-10-31
NCT00127686 Effect of Honey and Dextromethorphan on Nocturnal Cough and Sleep https://ClinicalTrials.gov/show/NCT00127686 Completed Penn State University 2006-12-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03363698 MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough https://ClinicalTrials.gov/show/NCT03363698 Recruiting Medical University of Warsaw 2021-09-30
NCT02847221 Cough Peak Flow for Extubation Prediction https://ClinicalTrials.gov/show/NCT02847221 Completed Hospices Civils de Lyon 2015-10-31
NCT02797756 Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough https://ClinicalTrials.gov/show/NCT02797756 Completed NYU Langone Health 2018-12-12
NCT02492126 Esophageal Motility in Reflux Induced Cough https://ClinicalTrials.gov/show/NCT02492126 Recruiting Mayo Clinic 2019-07-31
NCT01314287 Effect of Coughing on Oxygenation in the Post Anaesthetic Care Unit https://ClinicalTrials.gov/show/NCT01314287 Completed NHS Research and Development 2013-07-31
NCT01297790 Cough Responses to Tussive Agents in Health and Disease https://ClinicalTrials.gov/show/NCT01297790 Completed Manchester University NHS Foundation Trust 2011-05-31
NCT02034305 Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy https://ClinicalTrials.gov/show/NCT02034305 Recruiting University of Pittsburgh 2021-01-31
NCT01899183 Surgery in Chronic Cough GERD Related https://ClinicalTrials.gov/show/NCT01899183 Completed University of Bologna 2010-12-31
NCT01777867 Cough Reflex Sensitivity and Bronchial Hyper-responsiveness https://ClinicalTrials.gov/show/NCT01777867 Completed Mayo Clinic 2016-02-29
NCT01637649 Diaphragmatic Function in Stroke Patients. https://ClinicalTrials.gov/show/NCT01637649 Completed The Catholic University of Korea 2013-06-30
NCT01566968 Novel Endpoints in Cough Challenge Testing https://ClinicalTrials.gov/show/NCT01566968 Completed Manchester University NHS Foundation Trust 2012-04-30
NCT01515280 Hull Airway Reflux Questionnaire Scores Following Cough Treatment https://ClinicalTrials.gov/show/NCT01515280 Completed Hull University Teaching Hospitals NHS Trust 2013-07-31
NCT01399060 Cough Sensitivity and Taste Preferences https://ClinicalTrials.gov/show/NCT01399060 Completed Monell Chemical Senses Center 2011-12-31
NCT04000997 The Predictive Value of Peak Cough Flow for Endotracheal Extubation of Patients After Craniotomy https://ClinicalTrials.gov/show/NCT04000997 Recruiting Beijing Tiantan Hospital 2020-02-28
NCT03999203 A Cross-sectional Study to Measure Cough in Severe Asthma https://ClinicalTrials.gov/show/NCT03999203 Completed Queen’s University, Belfast 2019-12-30
NCT03983044 Comparison of Two Methods for Assessing Cough Capacity in Intensive Care Unit After Cardiac Surgery https://ClinicalTrials.gov/show/NCT03983044 Completed Centre Chirurgical Marie Lannelongue 2019-07-09
NCT03721224 Psychiatric Disorders in Children With Psychogenic Cough https://ClinicalTrials.gov/show/NCT03721224 Completed Bezmialem Vakif University 2018-12-01
NCT03638063 ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis https://ClinicalTrials.gov/show/NCT03638063 Recruiting Guangzhou Institute of Respiratory Disease 2020-07-31
NCT03635710 Smartphone Enabled Detection of Nocturnal Cough Rate and Sleep Quality as a Prognostic Marker for Asthma Control https://ClinicalTrials.gov/show/NCT03635710 Completed Cantonal Hospital of St. Gallen 2019-12-31
NCT01263626 Cough Monitoring Study https://ClinicalTrials.gov/show/NCT01263626 Completed Vanderbilt University 2012-01-31
NCT01217879 COugh Among Hypertensive Patients Treated With Telmisartan, Who Had to Stop previoUs ACE-i Treatment Due to couGH in Slovakia https://ClinicalTrials.gov/show/NCT01217879 Completed Bayer 2010-09-30
NCT01211171 COugh Among Hypertensive Patients Treated With Telmisartan, Who Had to Stop previoUs ACE-I Treatment Due to couGH in Poland https://ClinicalTrials.gov/show/NCT01211171 Completed Bayer 2009-12-31
NCT00907491 Accuracy of Cough Detection in Healthy Adults https://ClinicalTrials.gov/show/NCT00907491 Completed KarmelSonix Ltd. 2009-07-31
NCT00711399 Assessment of Cough and Wheeze With Breath Sound Documenting Device https://ClinicalTrials.gov/show/NCT00711399 Completed Carmel Medical Center 2009-09-30
NCT00660114 Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients https://ClinicalTrials.gov/show/NCT00660114 Completed AstraZeneca 2009-03-31
NCT00588627 Capsaicin Cough Threshold in Chronic Cough Due to Postnasal Drip https://ClinicalTrials.gov/show/NCT00588627 Completed Mayo Clinic 2008-12-31
NCT00353951 An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care https://ClinicalTrials.gov/show/NCT00353951 Completed Cardiff University 2007-07-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT04204148 To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy https://ClinicalTrials.gov/show/NCT04204148 Recruiting The First Affiliated Hospital of Soochow University 2020-03-31
NCT03831568 Mechanical Cough Augmentation in Children With NMD https://ClinicalTrials.gov/show/NCT03831568 Completed Oslo University Hospital 2019-01-31